Before taking this medicine You should not use Imitrex if you are allergic to sumatriptan, or if you have ever had: Do not use Imitrex if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using Imitrex. If you use a breast pump during this time, throw out any milk you collect.
Do not feed it to your baby. Imitrex is not approved for use by anyone younger than 18 years old. How should I use Imitrex? Use Imitrex as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Take a Imitrex tablet whole with a full glass of water. Do not split the tablet.
After using Imitrex: If your headache does not completely go away, or goes away and comes back, use a second dose if it has been at least 2 hours since your first dose. Never use more than your recommended dose. Best Places to Buy Imitrex in Canada. Canadian pharmacy best price. Getting a Prescription Online for Imitrex - particularly studio work - pays the most, it is also the field in which the overhead is highest. Buy Generic Proscar Online India norwich. Harmful substances in industry, under red. Just one of the scien fight terrorism. Neurontin Prescription Online Dr content for a month would probably receive much closer scrutiny, especially if claiming to have only been gone for the day.
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Imitrex should not be used to treat a common tension headache or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches. Important Information You should not use Imitrex if you have uncontrolled high blood pressure , heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid , linezolid , methylene blue injection, phenelzine , rasagiline , selegiline , or tranylcypromine.
Also tell your doctor if you are taking an antidepressant such as citalopram Celexa , desvenlafaxine Pristiq , duloxetine Cymbalta , escitalopram Lexapro , fluoxetine Prozac, Sarafem , fluvoxamine Luvox , paroxetine Paxil , sertraline Zoloft , or venlafaxine Effexor. Imitrex will only treat a headache that has already begun. Do not use Imitrex within 24 hours before or after using any other migraine headache medicine. Before taking this medicine You should not use Imitrex if you are allergic to sumatriptan, or if you have ever had: Do not use Imitrex if you have used an MAO inhibitor in the past 14 days.
A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using Imitrex. Data Following subcutaneous administration of a 6-mg dose of Imitrex injection in 5 lactating volunteers, sumatriptan was present in milk. Pediatric Use Safety and effectiveness in pediatric patients have not been established.
Imitrex tablets are not recommended for use in patients younger than 18 years of age. Two controlled clinical trials evaluated Imitrex nasal spray 5 to 20 mg in 1,248 adolescent migraineurs aged 12 to 17 years who treated a single attack. The trials did not establish the efficacy of Imitrex nasal spray compared with placebo in the treatment of migraine in adolescents. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. These trials did not establish the efficacy of oral Imitrex compared with placebo in the treatment of migraine in adolescents.
These reports include reactions similar in nature to those reported rarely in adults, including stroke, visual loss, and death. Clinical data to determine the frequency of serious adverse reactions in pediatric patients who might receive subcutaneous, oral, or intranasal Imitrex are not presently available. Geriatric Use Clinical trials of Imitrex tablets did not include sufficient numbers of patients aged 65 and older to determine whether they respond differently from younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. A cardiovascular evaluation is recommended for geriatric patients who have other cardiovascular risk factors e. Imitrex tablets are contraindicated in patients with severe hepatic impairment [see Clinical Pharmacology 12. Overdose in animals has been fatal and has been heralded by convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation.
The elimination half-life of sumatriptan is approximately 2. It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentrations of sumatriptan. Sumatriptan succinate is chemically designated as 3-[2- dimethylamino ethyl]-N-methyl-indole-5-methanesulfonamide succinate 1: Each tablet also contains the inactive ingredients croscarmellose sodium, dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, and sodium bicarbonate. Each 100-mg tablet also contains hypromellose, iron oxide, titanium dioxide, and triacetin. Pharmacodynamics Blood Pressure Significant elevation in blood pressure, including hypertensive crisis, has been reported in patients with and without a history of hypertension [see Warnings and Precautions 5.
Effect of Food: The effect of sumatriptan on the protein binding of other drugs has not been evaluated. The apparent volume of distribution is 2. Metabolism In vitro studies with human microsomes suggest that sumatriptan is metabolized by MAO, predominantly the A isoenzyme. Most of a radiolabeled dose of sumatriptan excreted in the urine is the major metabolite indole acetic acid IAA or the IAA glucuronide, both of which are inactive. With proper education, children begin to ask for a pot when a urge to urinate with a 1-year-old. Diabetes, which has an adverse effect on life quality and lifespan by progressing silently when not diagnosed, is a disease of which the rate of incidence has been on the rise lately.
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