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Following monoubiquitination, degradation of p53 is promoted by the additionof additional ubiquitins to the original ubiquitin monomers, creating chains ofubiquitin proteins which, when linked through ubiquitin lysine 48, target p53 fordegradation [ 26]. Macular degeneration tends to affect one cell at a time,while the healthy cells continue sending messages to your brain Macular degeneration tends to affect one cell at a time,while the healthy cells continue sending messages to your brain. The ability of the older adult tofunction in everyday activities, albeit with environmental andpharmacologic interventions, is a more meaningful measureof normalcy than are physical?

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