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SLE also raises the risk of miscarriages. Below are some conditions at which blood circulation of somebody could get compromised. All these place them at a heightened risk of heart problems too. Diltiazem Diltiazem: White or off-white crystalline powder with a bitter taste. Insensitive to light. Soluble in water, methanol, chloroform. Pharmacology Mode of action -. Antianginal, hypotensive, antiarrhythmic voltage-blocking calcium channels L — type and inhibits the entry of calcium ions in the depolarization phase cardiomyocytes and smooth muscle cells.

It relaxes smooth muskulatu vessels, lowers systemic vascular resistance. It has a dose-dependent antihypertensive effect in mild to moderate hypertension. The degree of reduction in blood pressure correlated with the level of hypertension in people with normal blood pressure is marked only the minimum of his fall. Antihypertensive action is shown in both the horizontal and vertical position. Rarely cause postural hypotension and reflex tachycardia. It does not change or slightly reduces the maximum heart rate under load. Long-term therapy is not soprovovozhdaetsya giperkateholaminemii, increased activity of the renin — angiotensin — aldosterone system. Decreases renal and peripheral effects of angiotensin II.

Antianginal effect is due to a decrease in myocardial oxygen demand, due to a decrease in heart rate and systemic blood pressure. It relaxes the smooth muscles of the coronary vessels in a concentration that does not cause negative inotropic effect. It slows down the ventricular rate in patients with high ventricular rate during fibrillation and atrial flutter. Restores normal sinus rhythm of paroxysmal supraventricular tachycardia, interrupts the circulation of excitation in the type of re — entry at nodal tachycardia and tachycardia with reciprocal conduct, including WPW — syndrome e Long-term use is accompanied by a slight increase in the sinoatrial PR interval on the ECG..

The syndrome sick sinus significantly prolongs sinus cycle. The action usually occurs within 3 minutes and reaches its maximum in the range of 2 — 7 min. Curtailment rate is maintained for 1 —. In patients with severe left ventricular changes heart failure, myocardial infarction, hypertrophic cardiomyopathy does not alter the contractility, the final Dad in the left ventricle and the pulmonary capillary wedge pressure. It has a minimal effect on the smooth muscles of the gastrointestinal tract. Long-term 8 months therapy is not accompanied by the development of tolerance and changes in plasma lipid profile. Able to cause regression of left ventricular hypertrophy in patients with hypertension.

In patients with acute myocardial infarction thrombolytic therapy on the background of plasminogen activator increased incidence of hemorrhagic complications in 5 times. C max is achieved through a 2 — 4 h Table. The volume of distribution of 5. Or 30 — 60 min Table. In the appointment of the inside. The duration of the ingestion of 4 — 8 hours see Table. And 12 — 24 h CBSA prolong.. It is metabolized in the liver by deacetylation, demethylation with the participation of cytochrome P450 in addition to conjugation. Do not drive or perform tasks that require alertness.

Limit alcoholic beverages. Avoid eating grapefruit or drinking grapefruit juice while using this medication. Contraindications Do not take Diltiazem if you are allergic to it or any ingredients of the medication, are pregnant or breastfeeding, or if you have certain types of heart rhythm problems in the absence of a pacemaker, very low blood pressure, left ventricular failure. Possible side effect Get emergency medical help if you have fainting, fast or slow heartbeats, feeling lightheaded, fever, sore throat, headache, red skin rash, peeling, swelling, rapid weight gain, nausea, stomach pain, low fever, loss of appetite, dark urine, jaundice yellowing of the skin or eyes , hives, difficulty breathing, swelling of your face, lips, tongue, stuffy nose, itching, dizziness, tired feeling, warmth, redness.

If you notice other effects not listed above, contact your doctor. Drug interactions Tell your doctor about all other medications you use, especially: Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor or prescriber about all prescription, over-the-counter, and herbal medications you are taking. Missed dose Take the missed dose as soon as possible. Skip the missed dose if it is time for your next scheduled dose. Don't take extra medicine to make up the missed dose. Overdose If you think you have overdosed the medicine seek emergency medical help at once. The overdose symptoms are extremely low blood pressure hypotension , heart failure, slow heart rate bradycardia , lightheadedness, dizziness, fainting, difficulty breathing.

Storage Store the medicine at room temperature between 68-77 degrees F 20-25 degrees C away from light and moisture. This action of diltiazem has two main effects; it slows down the rate at which the heart beats and it allows the blood vessels in the body to widen. When the heart beats more slowly, the pressure at which the blood is pumped out of the heart is reduced. When the blood vessels in the body relax and widen, this decreases the resistance that the heart has to push against in order to pump the blood around the body. Both these actions reduce the pressure within the blood vessels.

This means diltiazem can be used to lower high blood pressure. Slowing the heart rate also reduces the energy used by the heart to pump blood around the body. This in turn reduces the heart's need for oxygen. At the same time, widening the blood vessels improves the blood and therefore oxygen supply to the heart. Both these features mean that diltiazem can be used in the management of angina. The chest pain of angina is caused by insufficient oxygen supply to the heart. As diltiazem improves this oxygen supply, and also reduces the effort the heart has to make to pump blood, it can be used to prevent angina attacks.

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This means diltiazem can be used to lower high blood pressure. Slowing the heart rate also reduces the energy used by the heart to pump blood around the body. This in turn reduces the heart's need for oxygen. At the same time, widening the blood vessels improves the blood and therefore oxygen supply to the heart. Both these features mean that diltiazem can be used in the management of angina. The chest pain of angina is caused by insufficient oxygen supply to the heart. As diltiazem improves this oxygen supply, and also reduces the effort the heart has to make to pump blood, it can be used to prevent angina attacks.

Diltiazem capsules are a long-acting or 'modified-release' form of diltiazem. Use Diltiazem regularly to get the most benefit. Precautions Before taking Diltiazem you should talk with your doctor if you have heart disease, congestive heart failure, irregular heart rhythm arrhythmia , sick sinus syndrome, liver disease, liver failure, cirrhosis, kidney disease, low blood pressure, any allergies. This drug may make you dizzy. Do not drive or perform tasks that require alertness. Limit alcoholic beverages. Avoid eating grapefruit or drinking grapefruit juice while using this medication. Contraindications Do not take Diltiazem if you are allergic to it or any ingredients of the medication, are pregnant or breastfeeding, or if you have certain types of heart rhythm problems in the absence of a pacemaker, very low blood pressure, left ventricular failure.

Possible side effect Get emergency medical help if you have fainting, fast or slow heartbeats, feeling lightheaded, fever, sore throat, headache, red skin rash, peeling, swelling, rapid weight gain, nausea, stomach pain, low fever, loss of appetite, dark urine, jaundice yellowing of the skin or eyes , hives, difficulty breathing, swelling of your face, lips, tongue, stuffy nose, itching, dizziness, tired feeling, warmth, redness. If you notice other effects not listed above, contact your doctor. Drug interactions Tell your doctor about all other medications you use, especially: Interaction between two medications does not always mean that you must stop taking one of them.

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As diltiazem improves this oxygen supply, and also reduces the effort the heart has to make to pump blood, it can be used to prevent angina attacks. Diltiazem capsules are a long-acting or 'modified-release' form of diltiazem. This means that they are designed to release the diltiazem slowly and continuously over several hours to produce a steady blood level of the medicine throughout the day. Diltiazem capsules are designed to be taken once a day, at the same time each day. They should be swallowed whole and not chewed or crushed, as this would damage the modified-release action. What is it used for? Angina pectoris. Mild to moderate high blood pressure hypertension.

Treats high blood pressure and chest pain angina. Used to treat high blood pressure.

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