Store in airtight containers. Protect from light. A yellow crystalline powder. Soluble in water; slightly soluble in alcohol; practically insoluble in chloroform and in ether; soluble in solutions of alkali hydroxides and carbonates. Incompatibility Preparations of doxycycline hyclate have an acid pH and incompatibility may reasonably be expected with alkaline preparations or with drugs unstable at low pH. Adverse Effects and Precautions As for Tetracycline Gastrointestinal disturbances with doxycycline are reported to be less frequent than with tetracycline and doxycycline may also cause less tooth discoloration.
Oesophageal ulceration may be a particular problem if capsules or tablets are taken with insufficient fluid or in a recumbent posture: Dispersible tablets or liquid formulations should be used in elderly patients, who may be at greater risk of oesophageal injury. Unlike many tetracyclines , doxycycline does not appear to accumulate in patients with impaired renal function, and aggravation of impairment may be less likely. Incidence of adverse effects For the suggestion that doxycycline may cause fewer adverse effects than minocycline. Anosmia Anosmia or dysosmia absent or impaired sense of smell have occasionally been reported in patients receiving doxycycline, although the association has not been defmitely established.
Effects on intracranial pressure Doxycycline has been associated with benign intracranial hypertension; for further details, see under Tetracycline. Porphyria Doxycycline has been associated with acute attacks of porphyria and is considered unsafe in porphyric patients. Interactions As for Tetracycline. Doxycycline has a lower affinity for binding with calcium than many tetracyclines. Consequently its absorption is less likely to be affected by milk or food, although it is still affected by calcium-containing antacids and other divalent and trivalent cations such as aluminium, bismuth, iron, magnesium, and zinc; even intravenous doxycycline may be affected, although less so than when given orally.
The metabolism of doxycycline may be accelerated by drugs that induce hepatic enzymes such as alcohol chronic use , rifampicin, and antiepileptics including carbamazepine, phenobarbital, phenytoin, and primidone. It has been suggested that doxycycline could increase ciclosporin concentrations, but evidence for this seems to be scant. Antimicrobial Action As for Tetracycline. Doxycycline is more active than tetracycline against many bacterial species including Streptococcus pyogenes , enterococci , Nocardia spp. Cross-resistance is common although some tetracycline-resistant Staphylococcus aureus respond to doxycycline. Doxycycline is also more active against protozoa, particularly Plasmodium spp.
Pharmacokinetics For the general pharmacokinetics of the tetracyclines, see Tetracycline. Doxycycline is readily and almost completely absorbed from the gastrointestinal tract and absorption is not significantly affected by the presence of milk or food in the stomach or duodenum. Mean peak plasma concentrations of 2. After intravenous infusion of the same dose peak plasma concentrations are briefly somewhat higher, but become very similar to those after oral dosage on equilibration into the tissues. Its biological half-life varies from about 12 to 24 hours.
Doxycycline is more lipid-soluble than tetracycline. It is widely distributed in body tissues and fluids. However, the majority of a dose of doxycycline is excreted in the faeces after chelation in the intestines. Although doxycycline has been reported to undergo partial inactivation in the liver, some sources consider this doubtful; however, the kinetics of doxycycline have been reportedly altered in patients receiving drugs that induce hepatic metabolism. Doxycycline is stated not to accumulate significantly in patients with renal impairment, although excretion in the urine is reduced; increased amounts of doxycycline are excreted in the faeces in these patients.
Nevertheless, there have been reports of some accumulation in renal failure. Removal of doxycycline by haemodialysis is insignificant. Uses and Administration Doxycycline is a tetracycline derivative with uses similar to those of tetracycline. It may sometimes be preferred to other tetracyclines in the treatment of susceptible infections because of its fairly reliable absorption and its long half-life that permits less frequent often once daily dosing. It also has the advantage that it can be given with care to patients with renal impairment. However, relatively high doses may need to be given for urinary-tract infections because of its low renal excretion.
Doxycycline has antiprotozoal actions and may be given in conjunction with quinine in the management of falciparum malaria resistant to chloroquine. Solutions of doxycycline are also used for malignant effusions. Doxycycline is usually given orally as the base or its various salts, usually the hyclate. Doses are expressed in terms of doxycycline; doxycycline hyclate 115 mg is equivalent to about 100 mg of anhydrous doxycycline. Doxycycline capsules and tablets should be given with plenty of fluid, with the patient in an upright position, and well before going to bed. Doxycycline may be given with food or milk if gastric irritation occurs.
Dispersible tablets or liquid formulations are advisable in elderly patients. In patients in whom oral therapy is not feasible, doxycycline hyclate may be given by slow intravenous infusion of a solution containing 0. Infusions should be given over 1 to 4 hours. The usual adult dose, either orally or intravenously, is 200 mg of doxycycline on the first day as a single dose or in divided doses , followed by 100 mg daily. Doxycycline is effective in treating many types of pathogenic flora. This medication is primarily prescribed for infections involving aerobic and anaerobic microorganisms.
Doxycycline demonstrates high efficacy in the treatment of diseases caused by streptococcal origins such as staphylococci, salmonella, and E. This medication can also be used to treat such common diseases as cholera, tularemia, plague, and anthrax to which the causative agent is clostridia, a dysentery rod. Doxycycline is administered orally and is quickly absorbed. Most of the active ingredient is absorbed into the gastrointestinal tract so that the therapeutic effect is quickly achieved. The total concentration of antibiotic is observed two hours following administration.
Forms of Doxycycline Doxycycline is dispensed in the following dosage forms: Tablets are dispensed in 100 mg strength, 10 per pack Capsules are made of gelatin. The powder mixture determines the contents of the capsules with the presence of small impregnations of white hue. Five pills are contained per pack Liofilizate for injection. This form of Doxycycline is contained in ampoules of 100 mg strength. The drug is dispensed in 5 or 10 ampoules per package The primary indications for Doxycycline use are: Upper and lower respiratory tract infections e. Urinary infection e. Otorhinolaryngology diseases e.
Abnormalities of the intestine e. Infectious processes affecting the male and female genital organs and excretory system e. Inflammatory diseases of the digestive tract caused by microorganisms e. Infections of genital organs e. Infectious diseases of the whole organism e. Ophthalmic pathologies e. Osteomyelitis, infectious arthritis, and other diseases. In addition to use in primary treatment, antibiotics are widely used to prevent malaria and negative consequences after an abortion. Contraindications Hypersensitivity to antibacterial agents of the tetracycline group, particularly Doxycycline or its components.
Low level of leukocytes. Pathological processes of the liver. Children younger than 8 years of age. Lupus erythematosus.
It is available as brand and as generic drug. The medicine is administered for treatment of bacterial diseases and complications. User reviews of Doxycycline online. The key difference of this drug is its being effective as against a certain range of susceptible strains of bacteria so against protozoa thus performing a complex effect on a body. The medicine is commonly administered for treatment of various types of pneumonias, acne infection of skin as well as sexually passed infections as chlamydia. It is also effective against syphilis, cholera and Lyme disease.
For home treatment Doxycycline is commonly prescribed in pills, while for clinical treatment the drug is administered intravenously though the efficacy of the antibiotic does not depend on the route of administration. Before you will buy Doxycycline online, you must learn the indications, side effects of the drug as well as contraindications and precautions. For example, the drug commonly causes diarrhea and vomiting. For most of the patients Doxycycline increases the sensitivity of the skin to sun. The drug must be administered with caution in pregnant and breastfeeding women.
The treatment of infections with this antibiotic may lead to temporary problems with teeth as increased sensitivity and temporary discoloration of teeth enamel. Doxycycline belongs to the class of tetracyclinic antibiotics. It is a broad spectrum drug which works against protozoa and bacteria by preventing from protein synthesis. Protein production is a necessary condition for replication of DNA structures. By inhibiting protein synthesis the drug prevents the cells of bacteria to replicate their DNA structures and thus to divide.
The process of growth of bacteria depends on the multiplication of DNA structures. The bacteria stop growing and thus stop spreading to the other body parts. In most cases this is enough for the body to cope with the infection and to recover. Doxycycline is one of the safest antibiotics which must be in every home medicine box. You can buy Doxycycline online cheap without seeing your doctor. We recommend getting medical advice on cases, conditions, dosages and duration of treatment before you will get Doxycycline without prescription. As average drug Doxycycline may cause side effects, it is contraindicated with certain conditions acute or chronic as well as interacts with other drugs you can take occasionally or constantly.
What conditions does Doxycycline treat? Apart from all the conditions effectively treated with the antibiotics of tetracyclinic group, Doxycycline is effective against conditions that are not commonly treated with antibiotics. For example, this antibiotic performs great efficacy in treatment of prostatitis, acne and rosacea. While commonly these conditions have their own indications and treatments, recent studies have shown that commonly the reason of these conditions lasting too long is bacterial or protozoal complications. Thus administering Doxycycline antibiotic to treat these conditions performs amazing effect and fast recovery.
Mind that additional anti-inflammatory drugs are needed to get completely recovered. Doxycycline perfectly treats chlamydia and non-bacterial urethritis. Though there are many alternatives to this medicine, still Doxycycline is one of the safest, cheapest and top effective antibiotics for sexually passed infections. Doxycycline does not perform any effect on viral infections, thus it is not recommended to take this antibiotic against conditions of viral nature as flu, cold, fever and others. Moreover, it is not recommended to take Doxycycline in case of the nature of a bothering condition is unknown.
If you are not sure what type of infection you have bacterial, protozoal or viral , then it is not recommended to start any treatment not only with Doxycycline as this antibiotic performs a very potent anti-inflammatory effect and thus is able to mask the symptoms. Due to the mode of action, Doxycycline performs an antihelminitc effect. Doxycycline is only a prescription drug, thus a visit to your doctor is a must before you will order the first box of pills online cheap. The doctor will make necessary tests to diagnose the cause of the condition as well as will prescribe an optimum dosage and scheme of intake which will be of great effect for your individual case. The drug is available in different forms.
The efficacy of the medicine does not depend on the form of the drug. You can choose any of the forms which will be more convenient for you. Doxycycline is available in form of pills, capsules, syrup and powder for suspension. What should I know before taking Doxycycline without prescription? This information is a must-read no matter how you get the drug: In case you order Doxycycline online cheap without prior seeing your doctor, you must carefully read the medication guide provided with the drug. Mind that the leaflet provided by the drug manufacturer describes only average cases of treatment. If you doubt the efficacy or correctness of indication of Doxycycline without prescription, then consult your health care provider for individual recommendations.
Before you start taking the drug, please, mind the next cases: Allergic reactions Doxycycline may cause allergic reaction in patients who experiences hyper-sensitivity to the drugs of tetracyclinic group. If you do not know whether you are allergic to this drug or not, then do not start the treatment without prior consulting your health care provider. Your doctor will make necessary tests to indicate which drugs you are sensitive to. Infections of genital organs e. Infectious diseases of the whole organism e. Ophthalmic pathologies e. Osteomyelitis, infectious arthritis, and other diseases. In addition to use in primary treatment, antibiotics are widely used to prevent malaria and negative consequences after an abortion.
Contraindications Hypersensitivity to antibacterial agents of the tetracycline group, particularly Doxycycline or its components. Low level of leukocytes. Pathological processes of the liver. Children younger than 8 years of age. Lupus erythematosus. Hereditary disease characterized by impaired absorption of sugar in the body. A high value in the blood plasma of porphyrins, which are an important pigment of blood cells. Children over 12 years of age if the teenager weighs less than 45 kg. Side effects of Doxycycline Gastrointestinal tract e. How to take Doxycycline? Doxycycline is available in several forms and therefore the method of administration may vary. The daily dose of Doxycycline can be taken 1 or 2 times with a 12 hour time interval between doses.
The amount of Doxycycline administered is determined by the attending physician and depends on the severity of the disease, pathogen form, and patient age. Doxycycline tablets can be taken with or without food, but preferably before meals. Periostat [Vibramycin] is then prescribed by your dentist as an additional treatment. The oral hygiene routine explained by your dentist or dental hygienist should continue at the same time. The periodontium, which is made up of collagen fibres, is the part of the gum that gives support to each tooth and it is this part that is affected by periodontitis. Periodontitis is caused by the presence of bacteria at the gum line which can cause inflammation and infection of the gum.
The body releases enzymes into the gums which break down the collagen fibres around the tooth and allows these special cells to get to the site of infection. This can cause teeth to become loose or even fall out. Diagram 1 explains the causes of periodonitis. Periostat [Vibramycin] reduces the effect of the collagenase enzymes.
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